What is Regonat 40 Mg?

Regonat 40 Mg contains Regorafenib, an oral multi-kinase inhibitor used in the treatment of certain types of cancer.

It is primarily prescribed for patients with advanced cancers, including metastatic colorectal cancer, gastrointestinal stromal tumors (GIST), and hepatocellular carcinoma (HCC), who have previously been treated with other therapies.

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Uses of Regonat 40 Mg

Metastatic colorectal cancer for patients who have progressed after prior treatments.

Gastrointestinal stromal tumors (GIST) are used after the failure of other targeted therapies like imatinib.

Hepatocellular carcinoma (HCC) for patients who have been previously treat with sorafenib.

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Benefits of Regonat 40 Mg

Extends progression-free survival delays cancer progression in advanced-stage patients.

Targeted therapy specifically targets cancer cell growth and proliferation, sparing healthy cells.

Slows tumor growth inhibits several kinases responsible for the formation of new blood vessels in tumors (angiogenesis), thereby reducing tumor growth.

Improves quality of life and offers a treatment option when other therapies have failed, potentially improving survival rates.

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How does Regonat 40Mg work?

Regorafenib, the active ingredient in Regonat 40Mg, works by inhibiting multiple protein kinases involved in tumor growth, angiogenesis, and the development of metastases.

It blocks the signals cancer cells use to grow and spread, cutting off the blood supply to tumors and directly interfering with cell growth and division.

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How to take Regonat 40Mg?

Take Regonat 40mg orally with water, usually after a low-fat meal to reduce stomach irritation.

It is typically taken once daily for 3 weeks, followed by a 1-week break (a 4-week cycle).

Ideally taken at the same time each day to maintain consistent blood levels.

Dosage of Regonat 40Mg

• The usual starting dose for adults is 160 mg (4 tablets of 40 mg each) taken once daily for 3 weeks, followed by 1 week off. This is considered one treatment cycle.
• Dose adjustments may be required depending on tolerance, side effects, and the patient’s liver and kidney function.

Side Effects of Regonat 40 Mg

Common side effects include:

• Fatigue and weakness
• Loss of appetite
• Diarrhea
• High blood pressure
• Hand-foot syndrome (redness, swelling, pain on palms and soles)
• Weight loss
• Voice changes (hoarseness)
• Liver damage (hepatotoxicity)
• Severe bleeding
• Heart problems (myocardial ischemia)
• Gastrointestinal perforation
• Infections

Interactions of Regonat 40 Mg

Anticoagulants (e.g., warfarin) increase the risk of bleeding.

CYP3A4 inhibitors (e.g., ketoconazole) may increase the levels of Regorafenib in the blood, leading to more severe side effects.

CYP3A4 inducers (e.g., rifampicin) may reduce the effectiveness of Regorafenib.

Other cancer medications’ concurrent use with other chemotherapy agents requires close monitoring.

Precautions of Regonat 40 Mg

• Regular liver function tests are required, as Regorafenib can cause severe liver damage.
• Use with caution in patients with a history of bleeding or those on blood thinners.
• Monitor patients for heart-related side effects like high blood pressure or heart attack risk.
• Not recommended due to the potential harm to the fetus or baby.
• Avoid taking the medication before or after surgery, as it can affect wound healing.

Storage Information

Store Regonat 40 Mg at room temperature (20°C to 25°C), away from moisture and direct sunlight.

Check the expiry date before use.

Keep out of reach of children.

Frequently Asked Questions

Q: What is Regonat 40 Mg used for?

A: It is use to treat metastatic colorectal cancer, gastrointestinal stromal tumors (GIST), and hepatocellular carcinoma (HCC).

Q: Can I take Regonat 40 Mg with food?

A: Yes, it should be take after a low-fat meal to avoid stomach upset.

Q: How long does it take to see the effects of Regonat 40 Mg?

A: The effects vary, but patients are generally monitor over several treatment cycles to assess efficacy.

Q: Does Regonat 40 Mg cause liver problems?

A: Yes, liver toxicity is a severe side effect, and regular monitoring is require.

Q: Can Regonat 40 Mg be used in children?

A: It is not typically recommend for use in children unless specified by a specialist.

Q: Is Regonat 40 Mg a cure for cancer?

A: No, it is not a cure but a treatment that may help slow the progression of advanced cancers.